What attackers do. Attackers depend on a user doing something, such as opening a file, clicking a link, running a pasted command or launching an image, to start their code. Social engineering is the usual lever, and the technique serves the Execution tactic.
How to defend. Reduce what users can run with application control, keep protective file markings, and block common malicious file types. Train staff to recognise lures, including fake fixes that ask them to paste commands into a terminal. Endpoint detection should watch what user-launched files and pasted commands lead to.
Signs to look for. Look for scripts or executables started from download or temp folders, shells launched from the Run dialog with long commands, and browsers or email clients spawning interpreters. A common gap is assuming users will not run commands themselves.