What attackers do. Attackers rely on a user opening a malicious file, such as a document, script, shortcut or installer, to run their code. It usually follows phishing or a fake download and serves the Execution tactic.
How to defend. Use application control to block unapproved executables and scripts from user-writable locations, and keep protective file markings so downloaded files get extra scrutiny. Disable macros from the internet and change default file associations for script types so they open in a text editor. Train users to report unexpected files, and use endpoint detection to watch what opened files launch.
Signs to look for. Look for processes started from Downloads, temp or email cache folders, shortcut or script files launching interpreters, and Office applications spawning shells. Gaps often involve less common file types that are not covered by attachment filters.