What attackers do. After gaining access to an internal account, attackers send phishing messages from it to colleagues, who are more likely to trust a message from a known address. This serves the Lateral Movement tactic.
How to defend. Apply the same filtering to internal mail and chat as to external mail, protect accounts with phishing-resistant MFA and monitor for compromised mailboxes. Make it easy to report suspicious internal messages and act quickly to contain the sending account. Revoke sessions and reset credentials for the sending account as soon as compromise is confirmed.
Signs to look for. Look for internal accounts sending unusual volumes of messages, messages with links or attachments unlike the sender's normal pattern, and new inbox rules hiding replies. A common gap is internal mail bypassing security scanning.