What attackers do. Attackers send stolen data out using a different protocol from their main command and control channel, such as FTP, SMB, DNS or a custom encrypted protocol, to avoid controls focused on web traffic. This serves the Exfiltration tactic.
How to defend. Block outbound protocols the business does not need and force traffic through monitored egress points. Use internal DNS resolvers only and inspect DNS for tunnelling. Apply data loss prevention and network monitoring to detect unusual volumes or destinations.
Signs to look for. Look for outbound FTP, SMB or other uncommon protocols to the internet, unusually long or numerous DNS queries, and large transfers from hosts that rarely send data. A common gap is permissive egress rules on servers.