What attackers do. Attackers register or buy domain names to use for phishing, malware hosting or command and control, often choosing names that resemble legitimate brands. This serves the Resource Development tactic and happens before any contact with the victim.
How to defend. Monitor newly registered domains and certificate transparency logs for lookalikes of your brand, register common variants of your own domains, and use takedown services. Block newly registered domains at the proxy where feasible, and publish DMARC to protect your own domain from spoofing.
Signs to look for. Look for lookalike domains appearing in certificate logs or emails, and connections to domains only days old. A common gap is that this activity happens outside your network, so it needs external monitoring.